Exploration of sintering concept in the pharmaceutical science is relatively recent. The objective of this study was to investigate the release characteristic of matrix tablet consisting of a hydrophobic polymer and aceclofenac for sustain release formulation using different sintering techniques. Aceclofenac is a NSAID is an ideal candidate for designing sustaining drug formulation due to its frequent dosing and short biological half-life (4 hr). The aceclofenac tablet was prepared by using different polymers by direct compression method. The sintering of tablet was done by using different techniques like thermal sintering and microwave sintering. The sintered tablets were tested for weight variation, content uniformity, hardness, friability and in-vitro dissolution study. The sintered tablets showed more strength than unsintered tablet and sintered tablet show less drug release than the unsintered tablet. It can be concluded that as sintering time and temperature increases drug retardation also increases.
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